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evaluated the intradiscal administration of OP-1 in a rat disc degeneration model and found the greater production of extracellular matrix and inhibition in the pain-related behavior

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In summary, pioglitazone and vitamin E are now recommended as pharmacotherapies for biopsy-proven NASH patients with and without diabetes, respectively, although long-term efficacy or safety should be established (Table 1) [5,6,7,8]