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Excessive fat accumulation inflames adipose tissue during obesity and favors adipose tissue macrophages (ATM) polarization from an anti-inflammatory to a pro-inflammatory phenotype, leading to further recruitment and infiltration of macrophages and other immune cells

A.EstevamC

Digested peptides were loaded on a home-made C4 precolumn (Optimize Technologies) and separated on a home-made reversed-phase column (150 m i.d

GSH may have been oxidized to GSSG during sample preparation

This chemical modification binds the peptide to albumin in the blood, significantly extending its half-life and allowing stable GH pulses for days , rather than minutes