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Patients with missing clinical or molecular data were excluded from these analyses to maintain statistical rigor

Oncogenic MYC drives aberrant choline metabolism by transcriptionally upregulating CTP:phosphocholine cytidylyltransferase- ( PCYT1A ) (223), a key enzyme in phosphatidylcholine (PC) de novo biosynthesis

Indeed, multidrug and radiation resistance in tumor cells have been associated with higher intracellular levels of GSH, and increased level of GSH is a poor prognostic factor in many types of cancer (31)

Key drivers included scale from channel partnerships and the B2B2C go-to-market approach, sales force leverage from selling multiple conditions with one sales team, R&D efficiency from the flexible program architecture, and overall spending discipline

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