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Cohen, G

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The prodrug micelles loaded with V-9302 improved the bioavailability of V-9302 and demonstrated excellent anti-tumor activity by synergistically targeting two metabolic pathways (Luo et al., 2020)

As a result of overexpression GGCT, not only did the level of glutamate m + 5 decrease, but also the levels of downstream metabolites such as -KG m + 5, succinate m + 4, fumarate m + 4 and malate m + 4 in the TCA cycle were affected (Fig