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However, the therapy at this dosage also led to a high incidence of side effects such as joint pain (50% of patients) and swelling in the limbs (37% of patients) [13]

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Molecular Mechanisms of Incretin Receptor Agonism in Fibrosis The anti-fibrotic actions of incretin receptor agonists are likely mediated through a combination of direct receptor-mediated signalling and indirect systemic effects

The problem is what the studies actually show