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International guidelines in 2021 require the treatment of CSU to be upgraded from second-generation H1-antihistamines (sgAHs) to omalizumab and cyclosporine (214)

In particular, our analysis reveals an odds ratio of 3.11 (95% CI [1.33, 7.24]) when comparing the pancreatitis risk of patients reporting adverse effects at a cumulative dose of larger than 5300 mg and those at a cumulative dose of less than 5300 mg