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These include sudden onset of severe leg pain, particularly if unilateral and associated with swelling or warmth (which could suggest deep vein thrombosis), progressive weakness or numbness in the legs, loss of bladder or bowel control, or symptoms accompanied by fever or signs of infection

- Improvement of stretch marks, acne scars, and epidermal damage

TGF- signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling

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