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Other Approved & Off-Label Uses While primarily focused on glucose, the systemic nature of DPP-4 inhibition allows Tradjenta to be integrated into several endocrine management strategies: Primary Endocrinology Indications: Management of Type 2 Diabetes: Restoration of insulin-to-glucagon balance to lower HbA1c

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Combined with the study data showing near-complete absence in milk, the evidence suggests tirzepatide has a similarly favorable profile during lactation