Mechanistically, bixin suppresses the TLR4/MyD88/NF-B and TGF-1/Smad3 signaling axes, attenuating the secretion of proinflammatory cytokines such as TNF- and IL-1 (Jie-Qiong et al., 2020
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Access this article Similar content being viewed by others Abbreviations PD: Parkinsons disease 6-OHDA: 6-Hydroxy dopamine MDA: Malondialdehyde ROS: Reactive oxygen species RNS: Reactive nitrogen species MWM: Morris water maze OFA: Open field activity test MFB: Medial forebrain bundle TH: Tyrosine hydroxylase DAergic: Dopaminergic DRD1: Dopamine receptor D1 GLT-1: Glutamate transporter-1 ALCAR: Acetyl-l-carnitine VTA: Ventral tagmental area SNpc: Substantia nigra pars compacta PFC: Prefrontal cortex iNOS: Inducible nitric oxide synthase GFAP: Glial fibrillary acidic protein NeuN: Neuronal nuclei References Carvalho MM, Campos FL, Coimbra B, Pego JM, Rodrigues C, Lima R, Rodrigues AJ, Sousa N et al (2013) Behavioral characterization of the 6-hydroxidopamine model of Parkinsons disease and pharmacological rescuing of non-motor deficits
