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More recently, a meta-analysis study linked GSTT1-1 null polymorphism with an increased risk of coronary heart disease 43

Region-specific vulnerability in neurodegeneration: lessons from normal ageing

For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

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The resulting decrease in antioxidant capacity further exacerbates oxidative stress and neuronal vulnerability in HD [166]