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Moreover, vitamin C plays a crucial role in regulating iron metabolism by promoting ferroportinmediated iron export and inhibiting hepcidin expression

Independent HTS assessments of data generated by ToxCast and Tox21 in relation to metabolic disruption have found these to be inadequate with respect to reliability (160), and whilst there is great utility in HTS for the purposes of prescreening, for (pre)validation purposes with respect to the objective of the current exercise, they were not considered to contribute substantially to the WoE