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Historically, there was significant concern for notoriety bias (i.e., increased likelihood of case reporting when patients are exposed to a drug with a negative reputation), which was mitigated by studying disproportionality signals

As superoxide is subject to efficient dismutation by cellular superoxide dismutases, it is possible that NFT might directly interact with Keap1 to induce the observed release of Nrf2 and its escape from proteasomal degradation

Norman, A.W

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