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Gradual Introduction: Start with lower doses to allow your body to adjust

A plateau is typically defined as no measurable change over 3 to 4 weeks despite consistent adherence to treatment and lifestyle factors

Sci Hortic 123:521530 Gallego S, Pena L, Barcia R, Azpilicueta C, Iannone F, Rosales E, Zawoznik M, Groppa M, Benavides MP (2012) Unravelling cadmium toxicity and tolerance in plants: insight into regulatory mechanisms

None of these is worthless, but none is a substitute for a prospective, adequately powered clinical trial, which is exactly what the program eventually ran