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It acts downstream of differentiation by shaping fibroblastmatrix interactions, limiting prolonged myofibroblast survival, and supporting the transition from contractile remodeling to tissue maturation

Clinicians managing these presentations often run longer initial courses and then taper to a maintenance frequency, such as three to four times per week, before eventual discontinuation pending symptom assessment

It has previously been reported that drug assessment using a HFD-fed medaka model is feasible 8