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The journey began in the 1980s with research on Gila monster venom, culminating in the discovery of exendin-4, a stable, effective peptide for treating diabetes, demonstrating the progression from initial discovery to blockbuster diabetes medications

further investigations are needed to clarify whether the observed discrepancy is meaningful or not

The excessive infiltration of SMs into synovia causes articular immune dysfunction, accelerates the progression of synovitis, and leads to osteoclast activation and ultimate bone erosion and joint destruction 7,8

The zeta potential of all nanocarriers was negative ( 24 mV) (Fig

In patients with diabetes, niacin may increase hemoglobin A1c by approximately 0.20.3% with standard doses