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Side Effect Comparison Framework: Key Clinical Variables Tolerability differences between semaglutide and tirzepatide emerge across multiple factors beyond the drug itself

However, this inhibitory effect is significantly weakened in patients with T2DM, indicating that its potential application in diabetes treatment requires further investigation.241 Through this series of complex molecular and cellular mechanisms, GLP-1 plays a vital role in the physiological and pathological processes of metabolic diseases like T2DM.232,233,241,259 (Fig

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