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Periodontal infections are more severe and chronic and are fueled by a dysregulated neutrophil response and pro-inflammatory gingival milieu, and can further potentiate insulin resistance (60)

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Studies focus on its efficacy in modulating glucose homeostasis and observing the synergistic effects of triple-receptor activation on lipid metabolism in experimental models

The safety was preliminarily verified: The acute toxicity test showed that a single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice