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RCT randomized controlled trial, R randomized, NR non-randomized, SB single-blind, DB double-blind, IB investigator-blind, TC triple combination (2%, HQ, 0.05%, RA, 0.01%)

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Specifically, SIRT3 deacetylates and inhibits aldehyde dehydrogenase 2, which prevents the conversion of acetaldehyde to acetate, potentially leading to acetaldehyde toxicity 183

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