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About 30-40% of patients in the Cleveland Clinic series didnt see meaningful additional loss with phentermine addition

Phase III results for retatrutide are set to be released later in 2025 and in early 2026, but an earlier phase II trial recorded between a 7.2% and 17.5% reduction in body weight after 24 weeks, depending on the dose (7.2% on 1mg, 17.5% on 12mg), and up to a 24.2% reduction in body weight after 48 weeks for those on 12mg (-8.7% change for those on 1mg) 8

Your BMI is measured at the eligibility visit, and historical BMI documented in your medical record may also be considered

It means we do not have enough human data to confirm safety with the same confidence as injectable semaglutide

A vial and syringe give your provider more flexibility with dosing, but it requires you to measure and inject more carefully