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The major adverse effects of topical retinoids and topical vitamin C are local skin irritation, including erythema, peeling, dryness, burning and itching, which depend on the concentration and formulation of the product (129,130)

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They over drink, they over consume alcohol and the next day is they're horrendous

A subset of Appendix D are the Appendix B substances, which are subject to similar requirements as S8 drugs