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Journal of Physiology & Pharmacology, 72(4), 543556
Samocha-Bonet also examined the effect of oral L-glutamine [25 g], whole protein low in glutamine (25 g), or water on the concentration of incretin hormones and insulin response in well-controlled T2DM patients and found that the first-phase insulin response and total GLP-1 were enhanced following the ingestion of both L-glutamine and protein
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In humans, small intestinal epithelial cells convert Gln and glutamate to citrulline, which is then transported by the circulatory system to renal proximal tubular cells, where arginine is synthesized by arginine-succinate synthetase and arginine-succinate lyase in the urea cycle
By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus
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