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Declining NAD+ impairs energy, metabolism, skin health, and immunity, accelerating biological aging.[12][13] Research indicates that this loop can be interrupted by boosting NAD+, potentially reversing aspects of biological age as measured by epigenetic clocks

This can occur due to conditions such as pernicious anemia, gastrointestinal disorders like Crohns disease, or following gastrointestinal surgery

All answers reflect pre-clinical research contexts

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Pernicious anemia, a condition caused by a vitamin B12 deficiency, often goes unnoticed, leaving people feeling sluggish, weak, or even confused