gingivalis synergistically regulates three core pathways via the TLR4/NF-B signaling pathway: (1) iron metabolism imbalance (upregulation of TFRC and NCOA4 expression leading to intracellular iron overload), (2) lipid metabolism reprogramming (enhanced ACSL4 and LPCAT3 activity promoting polyunsaturated fatty acid phospholipid accumulation), (3) antioxidant defense collapse (downregulation of SLC7A11 and GPX4 triggering glutathione depletion and impaired lipid peroxide clearance)
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They may be used alone or synergistically with antifungals to alter gene expression related to adhesion, mycelial or biofilm formation, reduce extracellular polysaccharides, decrease surface hydrophobicity, or inhibit efflux pumps
Risk factors for vulvovaginal candidiasis: A case-control study among university students
