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That finding, combined with mechanistic studies suggesting GLP-1 agonists play a role in brain inflammation, metabolism, and vascular health, is what motivated the Alzheimer's Association to pair the drug class with its proven lifestyle intervention platform

HO-1 facilitates the breakdown of heme, resulting in the release of significant quantities of reactive iron ions, which then promote the Fenton reaction, ultimately producing lipid peroxides and causing ferroptosis in osteoblasts ( Figure 3 ) (124, 136)