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Aged hearts exhibit reduced activity of complexes I and IV, decreased mitochondrial membrane potential, and lower ATP synthesis capacity, collectively termed bioenergetic decline

Genetic variations in GLP-1 and GIP receptor genes, as well as variants in metabolic regulators like FTO and MC4R, may influence how your body responds to the medication

Activation of PGC-1 alters the metabolic phenotype through interactions with nuclear respiratory factor and peroxisome proliferator-activated receptor- [8-10], which leads to increased mitochondrial biogenesis and activity

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Ramping up slowly is advisable to avoid possible uncomfortable responses