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These consequences are particularly detrimental within neurons due to their high metabolic demand and limited regenerative capacity (Cobley et al., 2018)

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doi: 10.3390/molecules15053507 172 IlievI

As a widely used antihypertensive drug, losartan enhances vascular perfusion, thereby enhancing drug delivery and intratumoral invasion of immune effector cells and, on the other hand, enhances chemotherapy sensitivity by inhibiting IGF-1 signaling to reshape ovarian cancer and the microenvironment (140)

One important link connecting these two phenomena is the rhythmic secretion of glucagon-like peptide-1 (GLP-1), ensuring temporal coordination of nutrient deposition following energy intake