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One possibility is that mutations in Rett syndrome occur almost exclusively on the paternally derived X chromosome and are lethal in male embryos
de la Asuncin JG, del Olmo ML, Sastre J, Milln A, Pelln A, Pallard FV, Via J
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3.3.1 Parkinsons disease (PD) The primary pathologic hallmarks of PD are loss of dopaminergic neurons located in an area of the brain called the substantia nigra pars compacta, and the presence of Lewy bodies, intracellular aggregates of misfolded -synuclein, in dopaminergic neurons and likely contribute to the death of these neurons
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