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As shown in Figures 1FH, PAS and H&E staining showed mesangial matrix accumulation (black arrows) and enlarged glomerular volume (red arrows) in DKD mice, which were attenuated by HU treatment

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It may inhibit glucogenesis, lipid metabolism, adipocyte differentiation, and the transcriptional activities of several other nuclear receptors, including PPAR and ROR (Yin et al., 2007