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In a primary human hepatocyte spheroid model, TEAD1 inhibition reduced hepatic steatosis by altering central metabolic pathways controlling lipid homeostasis (158)

2018;97(5):10941109.e9

In a major clinical trial published in The New England Journal of Medicine , patients taking retatrutide lost an average of about 24% of their body weight after 48 weeks

Future large-scale, well-designed clinical trials will be essential to confirm their therapeutic potential, clarify the contribution of metabolic versus immunological effects, and define their role within the treatment algorithm of PsO and PsA