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To further understand the potential role of estrogen in regulating inflammatory stress, we stimulated two different types of macrophages (THP1-derived macrophages and liver resident primary Kupffer cells) with LPS in the presence and absence of estradiol and then analyzed the cytokine expression, IDO1, and Trp-catabolism

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The pharmacokinetic argument is the strongest

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For each item, the participants were asked to rate the frequency of experiencing specific problems on a five-point scale: 0 = never, 1 = hardly ever, 2 = occasionally, 3 = fairly often, and 4 = very often