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BPC-157: en modelos preclnicos promueve la angiognesis regulando al alza el receptor VEGFR2, induciendo su internalizacin y activando la va VEGFR2-Akt-eNOS, con aumento de la produccin de xido ntrico (PMID 27847966)
Curr Pharm Des 20:11261135 Seiwerth S, Brcic L, Vuletic LB, Kolenc D, Aralica G, Misic M, Zenko A, Drmic D, Rucman R, Sikiric P (2014) BPC 157 and blood vessels
The GLP-1s are FDA-approved
The belief is that peptide medicine is a weight loss business
A detailed analysis of the antiobesity action of fenfluramine disclosed that it directly activates hypothalamic POMC neurons through 5-hydroxytryptamine 2C (5-HT2C) receptors that are expressed on a majority of these cells [80]
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