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PMID: 25331030 Sigalos JT, Pastuszak AW

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ECs expressing higher levels of venous markers, such as Nrp2, Madcam1, Aplnr and Nr2f2 (Coup-TFII) , can be seen on the left side of the UMAP plot, subdivided into proliferative (G2/M and S phase) and two non-proliferative groups (Venous EC1 and Venous EC2)

Whilst this mechanism contributes to the medication's appetite-suppressing effects, it can initially cause feelings of fullness, bloating, or discomfort

(2024, September) Retatrutide is a novel triple-agonist targeting GLP-1, GIP, and glucagon receptors, showing in phase 2 trials that it can deliver remarkably large weight losses (up to ~24% over 48 weeks in people with obesity) along with strong improvements in HbA1c, lipid profiles, liver fat (in NAFLD), insulin sensitivity, and other cardiometabolic markers