While directly measuring neuroprotection in living patients is technically unfeasible, alternative strategies, such as monitoring pro-inflammatory markers or neuroprotective cytokines in the plasma of patients receiving istradefylline, could offer valuable mechanistic insights and serve as surrogate indicators of therapeutic activity [485]
Additionally, when the body is exposed to high oxidative stress, malnutrition, or an increase in toxic load from environmental contaminants, the need for glutathione increases
Interestingly, the blood Hcy of the same patients was normal (11.7 2.9 Mol) suggesting the occurrence of a follicle-specific impairment of Hcy metabolism in PCOS and a main role of Hcy in PCOS subfertility also in women with normal Hcy blood values
Co-corresponding author and co-first author Fabio Hecht, PhD, and co-first author Marco Zocchi, PhD, led the study in the Harris lab in the Department of Biomedical Genetics
[23] described a few properties of Thermosynechococcus elongatus BP-1 (TeGST) and Synechococcus elongatus PCC 6301 GSTs (SeGST)