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In the context of ARDS, ferroptosis contributes to the destruction of alveolar and endothelial cells, leading to increased vascular permeability, pulmonary edema, and impaired gas exchange

However, this has not been confirmed (Miller et al., 2006

[DOI] [PMC free article] [PubMed] [Google Scholar] [6].Lubos E, Kelly NJ, Oldebeken SR, Leopold JA, Zhang YY, Loscalzo J, Handy DE, Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation

Future investigations will elucidate the molecular mechanism of glutamine addiction by identifying the death pathways activating during the impairment of glutamine catabolism or when glutamine is limited

Systematic reviews of clinical studies show that IV and oral glutathione have promising effects on skin lightening and oxidative balance, although more long-term data are still needed