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Upon accumulation of per- and polysulfides, the attacking thiol of CstR quickly forms per- and polysulfide chains, and tri-, and tetrasulfide interprotomer crosslinks with the other cysteine, inhibiting the ability of CstR to bind to the target operator site 23, 24

Youd even be able to pinpoint the saturation pointthe dose where adding more peptide doesn't get you any more GH secretion

[PubMed: 2295831] 84