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Sikiric et al., 2006)

Because of its defined molecular profile, the compound is frequently used in laboratory studies examining peptide signalling and regulatory processes

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For instance, SKF 83822 is a functionally selective ligand biased towards D 1 -mediated signaling via adenylyl cyclase, that additionally causes seizures at high doses, 64 while SKF 83959 preferentially activates the D 1 /D 2 receptor heteromer and the associated phospholipase C response

The answer lies in gene expression