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Length: 7'39 Background Mast cells are often considered the sentinel first responders of the immune system because after originating in bone marrow they migrate to body tissues facing the external environment and react to exposure of foreign compounds (xenobiotics) by releasing a large number of inflammatory mediators, resulting in activation of the immune system and production of signs and symptoms of tissue inflammation (Voss et al, 2021)

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Animal Model:Ischemia (pMCAO) rats [4] Dosage:100 g/kg Administration:Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO)