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(2014) reported a generally lower level of metabolites in PD as compared to controls, with a specific decrease in 3-hydroxyisovaleric acid, tryptophan, and creatinine, a significant decrease in the levels of A-38 and A-42, and an increase in soluble amyloid peptide precursor (APP) in CSF of patients

It is upregulated in 75% of primary prostate tumors, and higher SLC44A4 expression correlates with higher Gleason score 161

For patients exhibiting low hormone sensitivity but significant OS damage, the focus should shift toward antioxidant therapy while appropriately adjusting the intensity and modality of hormone intervention