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Thymosin beta-4 (the molecule behind TB-500) is best supported for central neurorestoration and remyelination : driving oligodendrocyte-progenitor differentiation and remyelination, stimulating neurogenesis and angiogenesis in injured cortex and hippocampus, and promoting neurite outgrowth in models where lesion size does not change but function still improves
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But as people age, telomere length shortens, and the progressive shortening of telomers affects the health and lifespan of humans
While the primary endpoint (cerebral glucose metabolism) was not met, these findings suggest injectable GLP-1s may be more effective than oral formulations
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