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They share the same receptor pathway, and doubling up dramatically increases the risk of severe gastrointestinal side effects without proportional benefit

The peptide powerfully modulates inflammation by increasing microRNA-146a expression while decreasing pro-inflammatory cytokines including TNF-alpha, IL-6, IRAK1, and TRAF6

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Its effects are not just limited to one area and may also involve the brain and nerves, helping the body respond better to stress and injury