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A physician-supervised medical weight loss program is different from trying another diet app, supplement plan, or one-size-fits-all weight loss subscription

Hum Exp Toxicol 2012;31:643-651

You're not trying to replace the GLP-1's appetite effectsyou're supporting a different angle of metabolic health that helps preserve results during the transition

In the diabetes group, 44% gained weight, but 56% continued losing weight or maintained it

If you dont have any reason not to take it, such as kidney disease, creatine may be a good option for people with slow COMT variants who want to avoid methylfolate and methylB12 supplements