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Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

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Glutathione (GSH, -glutamylcysteinylglycine) the most abundant, endogenous, intracellular antioxidant, could protect mitochondria from oxidative stress, whereas GSH deficiency accelerates the rate of aging and aging-related diseases

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The intricate link between ROS production, Ca 2+ imbalance, and MAPK activation exemplifies the intricate network that governs the initiation and execution of paraptosis