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Based on the pharmacokinetic properties, GLP-1 RAs could be roughly divided into short-acting agonists which are administered once or twice daily, and long-acting agonists which are administered once weekly

These observations highlight a major limitation of first-generation KRAS inhibitors: while direct KRAS inhibition is feasible, durable disease control remains difficult to achieve with monotherapy

Abbreviation, H+, proton

NMR spectroscopy NMR experiments were performed using a Bruker 900 MHz NMR spectrometer equipped with a cryogenic probe (KBSI, Ochang) and a Bruker 600 MHz NMR spectrometer equipped with a cryogenic probe (GIST, Gwangju)

Important: Compounded drugs are not FDA-approved