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The underlying driver is the uneven pace at which national regulatory agencies are updating their clinical trial frameworks to reflect the operational realities of decentralized methodologies a structural gap that will require sustained harmonization effort across the ICH membership to resolve

Apart from CTLs, mesenchymal stem cells (MSCs) conjugated with an E-selectin-targeting peptide (CGSDITWDQLWDLMK) on the cell surface showed controlled adhesion and rolling through an interaction between the peptide on the stem cells and E-selectin on the endothelial cells 45

The genes were amplified by PCR using T4 primers (New England Biolabs)

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