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Within the locus coeruleus (a brainstem nucleus in the dorsal pontine tegmentum) the end product of the pathway is norepinephrine

Mapping the proteostasis network: from pathways to interactomes A fundamental challenge ahead is to move from pathway-level knowledge toward a comprehensive proteostasis interactome, capturing how proteostasis systems communicate, compensate and fail under disease stress

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The challenge was later withdrawn, but it drew attention to the complexities of managing artistic estates