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However, its poor water solubility binding limits its further clinical application

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155,156 While corticosteroids have shown limited efficacy and potential adverse effects in clinical trials, NSAIDs, particularly those with selective cyclooxygenase-2 inhibition, have demonstrated some protective effects in experimental models

Current knowledge is largely derived from preclinical studies investigating the biological processes involved, with a lack of clinical trials confirming these effects in human subjects

[DOI] [PubMed] [Google Scholar] 43.Kuchta A., Pacanis A., Kortas-Stempak B., wikliska A., Zitkiewicz M., Renke M., Rutkowski B