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10.1080/09603123.2023.2210109 159 NarkwicheanA.MaaloufW.BaumgartenM.PolanskiL.Raine-FenningN.CampbellB.et al (2017)

However, excessive or prolonged exposureparticularly to pyridoxinecan lead to sensory neuropathy, ataxia, and numbness

PMC 84931

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Many people who push through the initial four to six weeks of adjustment fatigue report that their baseline energy levels after treatment are significantly higher than they were before starting, not because retatrutide gives you energy, but because losing weight removes the energy-draining burden of excess body mass