According to Leerink analyst David Reisinger, retatrutide showed higher gastrointestinal side effects than Zepbound, as expected, plus much higher rates of dysesthesia. William Blairs Andy Shea acknowledged that the placebo-adjusted weight loss compares favourably to the 18% figure for Zepbound but predicted the drug will likely be limited to individuals at the higher end of the BMI spectrum. In plain terms: retatrutide works spectacularly, but its probably too punishing for routine use
It hasn't been a rocket ship to weight loss, but I'm steadily losing 1-2 pounds per week, and I haven't hit a plateau yet
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Your GP or endocrinologist can help differentiate between expected physiological adjustments and symptoms requiring intervention
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