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Role of intra-islet paracrine signaling in the effects of pharmaceutical targeting of GLP-1 As current therapies focusing on increasing insulin sensitivity and/or insulin secretion fail to cure diabetes, one potentially underappreciated target for diabetes treatment is the alpha-cell

doi: 10.1007/s10620-016-4054-0 8 TilgHMoschenARRodenM

Understanding its central role (amongst many things) in the Krebs cycle particular wrt to succinly CoA and energy production explains why so many people feel better after injection

All studies were interventional, meaning they actively tested GLP-1 as a treatment intervention rather than simply observing existing conditions

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