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Constipation may occur when food intake drops, fluid intake decreases, fiber changes, movement declines, or digestion slows

11, 12, 13 On one hand, it was observed in preclinical animal studies that a significant number of animals developed medullary thyroid carcinomas after long-term treatment with GLP1 analogs

This phenomenon was observed in the famous Minnesota Starvation Diet, where men in WW2 concentration camps were starved and were noted to have intrusive food thoughts, among many other side effects

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Another study on the effect of dulaglutide on stroke showed that dulaglutide reduced the incidence of stroke in middle-aged and elderly people with T2MD and other cardiovascular risk factors, but it cannot reduce the severity of stroke (88)